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3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC3) • Prevention and Screening in BRCA Mutation Carriers and Other Breast/Ovarian Hereditary Cancer Syndromes • Primary Breast Cancer Rectal Cancer • Biliary cancer • Gastric cancer • Oesophageal cancer • Cancer of the pancreas • Metastatic colorectal cancer • Anal cancer • Early colon cancer • Familial risk colorectal cancer • Hepatocellular carcinoma Chronic myeloid leukaemia • Newly diagnosed and relapsed mantle cell lymphoma • Multiple myeloma • Newly diagnosed and relapsed follicular lymphoma • Extranodal diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma • Acute lymphoblastic leukaemia • Peripheral T-cell lymphomas • Diffuse large B cell lymphoma • Chronic lymphocytic leukaemia • Hairy cell leukaemia • Philadelphia chromosome-negative chronic myeloproliferative neoplasms • Myelodysplastic syndromes • Hodgkin's lymphoma • Primary cutaneous lymphoma • Acute myeloblastic leukaemia in adult patients • Waldenstrom's macroglobulinaemia • Gastric marginal zone lymphoma of MALT type Management of infusion reactions to systemic anticancer therapy • Management of toxicities from immunotherapy • Management of febrile neutropaenia • MASCC and ESMO consensus guidelines for the prevention of chemotherapy and radiotherapy-induced nausea and vomiting • Treatment of dyspnoea in advanced cancer patients • Central venous access in oncology • Management of oral and gastrointestinal mucosal injury • Management of refractory symptoms at the end of life and the use of palliative sedation • Advanced care planning in palliative care • Bone health in cancer patients • Cancer, fertility and pregnancy • Management of chemotherapy extravasation • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy • Management of cancer pain • Management of venous thromboembolism in cancer patients • Prevention of chemotherapy and radiotherapy-induced nausea • Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients • Haematopoietic growth factors ESMO fosters the advancement of cancer research by supporting clinical trials workshops to inspire young oncologists from different disciplines across the globe to become the next generation of active researchers.The ESMO Designated Centres of Integrated Oncology and Palliative Care accreditation programme recognises cancer centres which provide comprehensive services in supportive and palliative care as part of their routine care.

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When I first spied him at a swing dance at the Supper Club in Manhattan, he was leaning against the mahogany bar drinking a martini in a neatly pressed button-down shirt. I go to Club Cocodrie in North Beach, where I know they’ll have swing dancing. After our first date, he calls me every day because he actually likes me.This went on for a year until he cheated on me with a waitress at Steak and Shake. He’d want to have sex, and I wanted to do it too, now that I’d been defiled. He’d start spending lots of time with his friends at Paddy O’s, the perfect place to complain about your crazy girlfriend over a pint of Guinness. It feels like my butt is being jackhammered by a giant apple corer. A relationship that doesn’t allow me to be a human being with needs and preferences isn’t worth having, no matter how good it looks on the outside.But after we’d have sex, I’d feel like a slut and become that needy girl every man is afraid of. And before long, he’d stop calling and break up with me. And when you call him back, respond to everything he says with, That’s awesome! When Liam didn’t call for more than a week, I didn’t cave. I sat shivering on my futon in my drafty Victorian apartment, staring at my cordless phone, willing it to ring. Maybe I was cheating myself by not believing I deserved a man who could give me the support and attention I craved. My heart is pounding as I stare at the twinkling Manhattan skyline.After he promised he would, I made him cuddle me for hours. We’d look deeply into each other’s eyes at a fancy restaurant where they comb your tablecloth. That’s when he asked me to spend New Year’s with him. He pulls back my pink lace thong and after some shoving and a lot of lube, he puts it in.We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale.

Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes.

The animal experiments which would be necessary to address these toxicological issues were rated unethical because tattoos are applied as a matter of choice and lack medical necessity, similar to cosmetics.

Even though toxicological data might be available for some ink ingredients individually, information on in vivo interactions of the ink’s components and their fate within the body is rare.

After healing, particles are present in the dermis and in the sinusoids of the draining lymph nodes. It can thus be expected to find a broad range of elements in tattooed human tissue—among them the sensitizers nickel (Ni), chromium (Cr), manganese (Mn), and cobalt (Co)—as parts of color-giving pigments or element contamination, and the identities and size ranges of pigment particles migrating from subepidermal skin layers towards lymph nodes have never been analytically investigated in humans before.

The average particle size in tattoo inks may vary from .

Altogether we report strong evidence for both migration and long-term deposition of toxic elements and tattoo pigments as well as for conformational alterations of biomolecules that likely contribute to cutaneous inflammation and other adversities upon tattooing..